Do you encounter the error “the set of folders cannot be opened” when launching Outlook? The leading cause behind this error is the interference from Outlook add-ins. Other possible causes include issues with your email profile, corruption of your Outlook profile, or corrupted OST and data files.

Likewise, using an incompatible version of Outlook or the same email address in multiple mail apps may also result in an error. Here are some fixes you should apply to resolve the issue.

Run Outlook as an Administrator in Windows

1. Perform Some Preliminary Checks

Before moving on to any serious troubleshooting, perform the following preliminary checks first, as they may resolve the error right away:

If the basic checks and fixes do not resolve the error, it’s time to move on to serious troubleshooting.

Run Outlook in Safe Mode by Running a Command in Windows

2. Check for Add-In Interference

The add-in interference is the leading cause of Outlook not launching and presenting the “the set of folders cannot be opened” error, as reported by numerous users on various online forums. Running Outlook in Safe mode is the best way to confirm that since it launches the app without add-ins and other elements.

PressWin + R,type"Outlook.exe /safe"and hitEnterto launch Outlook in safe mode.

If the app launches without an error, the add-in interference must have been the culprit. Therefore, stay in safe mode and turn off any interfering add-ins. Here’s how:

3. Check for Issues With the OST File

The mislocated OST file or its corruption can also lead to the error. Therefore, ensure the file is at its original location and recreate it to eliminate the possibility of file corruption. Here’s how:

To ensure that the OST file is not corrupt, copy it to a safe location outside the Outlook installation folder. Then, right-click and delete the main OST file.

Select Options in the File Tab of Outlook

After that, restart Outlook, and it will automatically recreate the OST file and download the data from the Exchange Server. If you decide to go this route, remain connected to the internet.

4. Check for Issues With Your Outlook Profile

Outlook uses the Outlook profile to store information about your email accounts, data files, and other client settings. Profile corruption can prevent Outlook from loading the necessary data at launch and can present the “set of folders cannot be opened” error. To rule out profile corruption as the cause of the problem, follow these steps:

If Outlook launches successfully, a corrupt profile could be to blame. So, continue to use the new profile after adding your account. If switching profiles does not help, go to the next step.

Go to Mail Option in the Windows Control Panel

5. Look for Issues With the Navigation Pane

Misconfigured navigation pane settings or corrupted XML files, which store the navigation pane settings, can also prevent Outlook from opening and presenting the error. To eliminate this possibility, you should reset the navigation pane in Outlook that will reset the configuration to its default settings. PressWin + R, type"outlook.exe /resetnavpane"and hitEnter.

After that, relaunch Outlook. If resetting the navigation pane doesn’t work, you should delete the XML file manually. To do this, pressWin + R, type"%localappdata%\Microsoft\Outlook"and hitEnter. After that, delete any XML files you find in this folder.

Ensure the File Type Is OST by Going to Properties in the Windows File Explorer

Then, restart Outlook from scratch, and it will recreate the XML file with default settings. There’s a good chance that it will resolve the issue.

6. Repair the Outlook PST Files

PST files store data about contacts, calendars, events, and messages. If the error window indicates that Outlook could not open the PST file, then the file could be corrupt, which could be why Outlook presents the error. Therefore, you can fix it by repairing the files. To repair the corrupted data files, follow the below steps:

If you can’t locate the Outlook folder in the path mentioned above, see ourguide on repairing the PST filefor the exact path.

7. Run the Microsoft Support and Recovery Assistant

If none of the above fixes resolves the error, run the Microsoft Support and Recovery Assistant, Microsoft’s recommended tool for fixing issues with Microsoft Office products.

Here’s how to download and use the tool:

If any underlying problem with the Outlook client contributed to this issue, running this tool will most likely resolve the issue.

Run Outlook on Windows Without a Hitch

Running into irritating errors when launching the Outlook client can hinder our productivity. Hopefully, you now better understand what causes the “the set of folders cannot be opened” error. In addition, by carefully applying the fixes listed above, you should be able to fix the error and launch Outlook successfully.